1991.09 – 2002.07 黑龙江中医药大学 本科，硕士，博士
2002.09 – 2004.08 中国科学院上海药物研究所博士后
2004.09 – 2006.11 中国科学院上海药物研究所，天然药物课题组，副研究员
2006.11 – 2015.12 色情片 ，生物药学系（原微生物与生化药学教研室）抗病毒药物研究室，讲师
2016.01至今 色情片 ，生物药学系（原微生物与生化药学教研室）抗病毒药物研究室，副教授
1.参与国家自然科学基金委员会,区域创新发展联合基金重点支持项目：芩百清肺浓缩丸治疗支原体肺炎的免疫调控与整合作用机制（2026/01至2029/12）
2.主持国家自然科学基金《中医药防治病毒性肺炎基础研究》专项：宣白承气汤通过保护血管内皮屏障防治重症病毒性肺炎的机制与药效物质研究（2022/1-2024/12）
3.主持国家自然科学基金面上项目：基于肠道粘膜免疫调控流感病毒诱导肺-肠组织损伤的肺与大肠表里反馈与干预机制研究（2017/1—2020/12）
4. 参与国家自然科学基金重点项目：清热解毒方药治疗肺部感染的免疫调控机制与药效物质（2021/1-2025/12）
5. 主持国家自然科学基金面上项目：基于TLR7/MyD88/TRAF-6通路和代谢组学的寒热并用法治疗H1N1病毒性肺损伤机制研究（2012/1—2015/12）
6. 主持国家自然科学基金青年项目：中药有效成分XJ032抗柯萨奇病毒作用机理研究(2006/1-2008/12)
华润三九医药股份有限公司、上海医药集团、中科院上海药物研究所、中科院昆明植物研究所、江苏省中医研究院等。
中药防治肺感染药效评价、作用机制及药效物质研究；
主讲和参讲《生物药物学》、《人类与病毒的斗争》、《生物技术药物》、《生物制药技术》本科多层次（专选，研讨，通识）及《生物制药技术与新药》研究生课程。
1. Xueyue Song, Linfeng Guo, Weichen Xu,Ting Wang,Daofeng Chen,Yan Lu,Xunlong Shi, Jinjun Shan, Haiyan Zhu*. Xuanbai Chengqi decoction targets sphingolipid metabolism: A novel strategy to preserve pulmonary endothelial barrier integrity in severe viral pneumonia. Jornal of Ethnopharmacology. 2025, 356:120780.
2. Xueyue Song, Ting Wang, Miao Ye, Xunlong Shi, Daofeng Chen, Yan lu, Haiyan Zhua* .Amygdalin regulated vasoactive intestinal peptide receptor to protect alveolar epithelial barrier against lung injury induced by influenza A virus.Chinese Medicine. 2025,20(1):154.
3. Linfeng Guo, Weilian Bao, Shuiyuan Yang , Yang Liu , Jiaren Lyu, Ting Wang, Yan Lu, Hong Li, Haiyan Zhu *, Daofeng Chen* . Rhei Radix et Rhizoma in Xuanbai-Chengqi decoction strengthens the intestinal barrier function and promotes lung barrier repair in preventing severe viral pneumonia induced by influenza A virus. J ournal of Ethnopharmacol，2023，30:117231.
4. Chenchen Shi, Chang Su, Lifeng Cen, Lei Han, Jianguo Tang, Ze tian Wang, Xunlong Shi, Dian wen Ju, Yiou Cao *, Haiyan Zhu *. Vunakizumab-IL22, a novel fusion protein, promotes intestinal epithelial repair and protects against gut injury induced by the influenza virus. Biomedicines，2023, 11(4)：1160.
5. YuanZhen Hao, LiFeng Cen, Ting Wang, Tong Yi, Xun-Long Shi, HuiJuan Duan, Zhi Dai, HaiYan Zhu*, JianGuo Tang*. The protective effect of 999 XiaoErGanMao granules on the lungs and intestines of influenza A virus-infected mice.Pharmaceutical biology，2023,61(1): 630-638.
6. Chenchen Shi, Lishuang Zhou, Hong Li, Xunlong Shi, Yunyi Zhang, Yan Lu, Haiyan Zhu*, Daofeng Chen*.Intestinal microbiota metabolizing Houttuynia cordata polysaccharides in H1N1 induced pneumonia mice contributed to Th17/Treg rebalance in gut-lung axis. International journal of biological macromolecules,2022，221:288-302.
7. Jinlin Huo, Ting Wang, Bokai Wei, Xunlong Shi, Aidong Yang, Daofeng Chen, Jing Hu, Haiyan Zhu*.Integrated network pharmacology and intestinal flora analysis to determine the protective effect of Xuanbai-Chengqi decoction on lung and gut injuries in influenza virus-infected mice.Journal of Ethnopharmacology，2022,298:115649.
8. Rong Tian, Haiyan Zhu*, Yan Lu , Xunlong Shi , Peng Tu , Hong Li , Hai Huang , Daofeng Chen*. Therapeutic potential of 2-Methylquinazolin-4(3H)-one as an antiviral agent against influenza A virus-induced acute lung injury in mice.Molecules, 2022, 27(22):7857.
9. Zetian Wang, Liping Yin, Yue Qi, Jiali Zhang, Haiyan Zhu*, Jianguo Tang *.Intestinal Flora-Derived Kynurenic Acid Protects Against Intestinal Damage Caused by Infection Activation of Aryl Hydrocarbon Receptor. Frontiers in microbiology，2022,DOI ：10.3389/fmicb.2022.934786
10. Tong Yi , Wenxin Ding, Yuanzhen Hao, Lifeng Cen, Jiyang Li, Xunlong Shi, Ting Wang, Daofeng Chen, Haiyan Zhu*.Neutrophil extracellular traps mediate severe lung injury induced by influenza A virus H1N1 in mice coinfected with Staphylococcus aureus. Microbial pathogenesis，2022,27:166.
11. Lifeng Cen, Tong Yi, Yuanzhen Hao, Chenchen Shi, Xunlong Shi, Yan Lu, Daofeng Chen, Haiyan zhu*. Houttuynia Cordata Polysaccharides alleviate the ulcerative colitis by restoring the intestinal homeostasis. Chinese Journal of Natural Medicines. 2022,DOI:10.1016/S1875- 5364 (22) 60 220-6
12.Lei Han, Chenchen Shi, Xian Zeng, Lifeng Cen, Xiaobin Mei, Jiajun Fan, Dianwen Ju, Haiyan Zhu*. A novel bifunctional fusion protein, vunakizumab-IL22, for protection against pulmonary immune injury caused by influenza virus. Frontiers in Immunology, 2021, doi: 10.3389/ fimmu.2021.727941
13.Chenchen Shi, Haiyan Zhu*, Hong Li, Donglin Zeng, Xunlong Shi, Yunyi Zhang, Yan Lu, Lijun Ling, Changyue Wang, Daofeng Chen*. Regulating the Balance of Th17/Treg cells in Gut-Lung Axis Contributed to the Therapeutic Effect of Houttuynia cordata Polysaccharides on H1N1-induced Acute Lung Injury. International Journal of Biological Macromolecules，2020,158,52-66.
14.PingGeng #, Haiyan Zhu#, Wei Zhou, Chang Su, Mingcang Chen, Chenggang Huang, Chengjie Xia, Hai Huang, Yiou Cao, Xunlong Shi*. Baicalin inhibits influenza A virus infection via amplification of M1 macrophage polarization. Frontiers in Pharmacology, 2020,11, doi: 10.3389/fphar.2020.01298.
